Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Apr 15;88(8):3451-4.
doi: 10.1073/pnas.88.8.3451.

Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration

H Fathallah-Shaykh  1 , S Wolf, E Wong, J B Posner, H M Furneaux
Affiliations

Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration

H Fathallah-Shaykh et al. Proc Natl Acad Sci U S A. .

Abstract

Antibody-associated paraneoplastic cerebellar degeneration (the Yo syndrome) is an uncommon disorder in which an immune response is specifically directed against tumor tissue and the cerebellum. Screening of a lambda expression library has resulted in the isolation of cDNA clones that encode the major antigen recognized by serum from these patients. The fusion protein produced by the cDNA clones provides the basis of a simple diagnostic assay for this neurological syndrome. The occurrence of leucine-zipper and zinc-finger motifs in the predicted open reading frame suggests that this protein plays a role in the regulation of gene expression.

PubMed Disclaimer

References

    1. Brain. 1965 Sep;88(3):465-78 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 - PubMed
    1. Neurology. 1986 Sep;36(9):1163-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4552-6 - PubMed
    1. Science. 1988 Jun 24;240(4860):1759-64 - PubMed

Publication types

MeSH terms