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Case Reports
. 2008 Oct;18(4):169-72.
doi: 10.4103/0971-4065.45294.

Nephrotic range proteinuria in c-ANCA-positive crescentic glomerulonephritis with linear immune deposits

N P Singh  1 , S Gulati, V Garg, P Beniwal, S Garg
Affiliations
Case Reports

Nephrotic range proteinuria in c-ANCA-positive crescentic glomerulonephritis with linear immune deposits

N P Singh et al. Indian J Nephrol. 2008 Oct.

Abstract

The three broad groups of rapidly progressing glomerulonephritis are anti glomerular basement membrane (anti-GBM) disease, renal vasculitis characterized by antineutrophil cytoplasmic antibody positivity, and a heterogeneous group with granular immune deposits. Anti-GBM disease with cytoplasmic antineutrophilic antibodies (c-ANCA) positivity (type III disease) is not known to present with nephrotic syndrome. We report here a rare presentation of nephrotic syndrome in Type III disease. Larger studies are warranted to determine whether the amount and/or type of immune deposits decide the range of proteinuria. These studies are also required to elucidate the impact of immune complex deposition on renal disease in c-ANCA-positive glomerulonephritis and to outline its pathogenetic mechanism.

Keywords: Anti-GBM disease; nephrotic syndrome; rapidly progressive glomerulonephritis.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Fig. 1
Fig. 1
A glomerulus showing fibrocellular crescents (H&E ×150)
Fig. 2
Fig. 2
Immunofluorescence staining showing glomeruli with linear positivity for IgG (×400)
See this image and copyright information in PMC

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