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. 2009 Jul;16(3):107-11.
doi: 10.4103/0974-9233.56219.

Results from the tube versus trabeculectomy study

Steven J Gedde  1
Affiliations

Results from the tube versus trabeculectomy study

Steven J Gedde. Middle East Afr J Ophthalmol. 2009 Jul.

Abstract

The Tube Versus Trabeculectomy (TVT) Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube shunt surgery to trabeculectomy with mitomycin (MMC) in eyes with previous cataract and/or failed glaucoma surgery. Tube shunt surgery was more likely to maintain intraocular pressure (IOP) control and avoid persistent hypotony, reoperation for glaucoma, or loss of light perception vision than trabeculectomy with MMC during the first year of follow-up. Both surgical procedures had similar IOP reduction at 1 year, but less supplemental medical therapy was used following trabeculectomy. The incidence of postoperative complications was higher after trabeculectomy with MMC relative to tube shunt surgery, but serious complications associated with vision loss and/or reoperation developed with similar frequency after both of the procedures. There was no significant difference in the rate of vision loss following trabeculectomy with MMC and tube shunt surgery after 1 year of follow-up. Cataract progression was common, but occurred with similar frequency with both of the surgical procedures.

Keywords: Trabeculectomy; Tube Versus Trabeculectomy Study; tube shunt.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Intraoperative photograph of tube shunt surgery
Figure 2
Figure 2
Intraoperative photograph of trabeculectomy with mitomycin C
Figure 3
Figure 3
Kaplan-Meier plots of the probability of failure in the Tube Versus Trabeculectomy (TVT) Study
See this image and copyright information in PMC

Comment in

References

    1. Ramulu PY, Corcoran KJ, Corcoran SL, Robin AL. Utilization of various glaucoma surgeries and procedures in Medicare beneficiaries from 1995 to 2004. Ophthalmology. 2007;114:2265–70. - PubMed
    1. Chen PP, Yamamoto T, Sawada A, Parrish RK, 2nd, Kitazawa Y. Use of antifibrosis agents and glaucoma drainage devices in the American and Japanese Glaucoma Societies. J Glaucoma. 1997;6:192–6. - PubMed
    1. Joshi AB, Parrish RK, Feuer WF. 2002 Survey of the American Glaucoma Society Practice preferences for glaucoma surgery and antifibrotic use. J Glaucoma. 2005;14:172–4. - PubMed
    1. Gedde SJ, Schiffman JC, Feuer WJ, Parrish RK, 2nd, Heuer DK, Brandt JD, et al. The Tube Versus Trabeculectomy Study: Design and baseline characteristics of study patients. Am J Ophthalmol. 2005;140:275–87. - PubMed
    1. Gedde SJ, Herndon LW, Brandt JD, Budenz DL, Feuer WJ, Schiffman JC. Surgical complications in the Tube Versus Trabeculectomy Study during the first year of follow-up. Am J Ophthalmol. 2007;143:23–31. - PubMed

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