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Randomized Controlled Trial
. 2010 Jun;21(6):711-9.
doi: 10.1007/s00192-010-1100-x. Epub 2010 Feb 9.

The effects of drug and behavior therapy on urgency and voiding frequency

Kathryn L Burgio  1 , Stephen R Kraus, Diane Borello-France, Toby C Chai, Kimberly Kenton, Patricia S Goode, Yan Xu, John W Kusek; Urinary Incontinence Treatment Network
Affiliations
Randomized Controlled Trial

The effects of drug and behavior therapy on urgency and voiding frequency

Kathryn L Burgio et al. Int Urogynecol J. 2010 Jun.

Abstract

Introduction and hypothesis: The objective of this study was to examine the effects of drug therapy alone and combined with behavioral therapy on urgency and 24-voiding frequency in women with urge-predominant incontinence and to identify predictors of change.

Methods: A planned analysis of data from a multi-site, randomized, controlled trial (N = 307). Bladder diaries were used to document voids, incontinence, and urgency severity.

Results: Urgency scores decreased significantly within both treatment groups, but changes did not differ between groups (p = 0.30). Improvement in urgency was associated with greater baseline urgency (p < 0.0001) and black ethnicity (p = 0.03). Voiding frequency increased with drug alone and decreased slightly with combined therapy (p = 0.009), and improvement was associated with combined treatment (p < 0.0001), higher baseline frequency (p < 0.0001), and lower baseline incontinence episode frequency (p = 0.001).

Conclusions: Although combined drug and behavioral therapy does not appear to improve urgency more than drug alone, it resulted in better outcomes on voiding frequency.

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Conflict of interest statement

Conflict of Interest: This study was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases. Pfizer, Inc. provided additional support, including donation of study drugs and funding. Four of the authors have a financial relationship with Pfizer. Disclosures of these and other financial relationships appear in the Acknowledgements section.

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