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Comparative Study
. 2010 Feb 21;16(7):862-7.
doi: 10.3748/wjg.v16.i7.862.

Colorectal cancer prognosis twenty years later

Luis Bujanda  1 , Cristina Sarasqueta, Elisabeth Hijona, Lander Hijona, Angel Cosme, Ines Gil, Jose Luis Elorza, Jose I Asensio, Santiago Larburu, José M Enríquez-Navascués, Rodrigo Jover, Francesc Balaguer, Xavier Llor, Xavier Bessa, Montserrat Andreu, Artemio Paya, Antoni Castells; Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Collaborators, Affiliations
Comparative Study

Colorectal cancer prognosis twenty years later

Luis Bujanda et al. World J Gastroenterol. .

Abstract

Aim: To evaluate changes in colorectal cancer (CRC) survival over the last 20 years.

Methods: We compared two groups of consecutive CRC patients that were prospectively recruited: Group I included 1990 patients diagnosed between 1980 and 1994. Group II included 871 patients diagnosed in 2001.

Results: The average follow up time was 21 mo (1-229) for Group I and 50 mo (1-73.4) for Group II. Overall median survival was significantly longer in Group II than in Group I (73 mo vs 25 mo, P < 0.001) and the difference was significant for all tumor stages. Post surgical mortality was 8% for Group Iand 2% for Group II (P < 0.001). Only 17% of GroupI patients received chemotherapy compared with 50% of Group II patients (P < 0.001).

Conclusion: Survival in colorectal cancer patients has doubled over the past 20 years. This increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality.

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Figures

Figure 1
Figure 1
Kaplan-Meier analysis of overall survival in the different groups.
Figure 2
Figure 2
Kaplan-Meier analysis of overall survival and the stage of colorectal cancer according to the group of patients.
See this image and copyright information in PMC

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