[The role of postprandial hyperglycemia in the development of cardiovascular diseases in type 2 diabetes mellitus]

Abstract

The aim of this clinico-epidemiological study was to elucidate the role of postprandial hyperglycemia (PH) and high glucose level 2 hours after glucose load in the development of cardiovascular disorders (CDD) in patients with type 2 diabetes mellitus and in the general population. Medical interventions to reduce PH decrease the risk of CDD. Pathophysiological studies show the involvement of oxidative stress in pathogenesis of CDD in cases with PH. Acute hyperglycemia increases heart rate and arterial pressure, disturbs myocardial perfusion and contractility, causes endothelial dysfuncton and atherosclerosis. The following preparations are recommended to subjects with DM2 and PH: alpha-glucosidase inhibitors, glynides, ultrashort-acting insulin analogs, dipeptidylpeptidase-4 inhibitors, exenatide (incretin mimetic).