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Editorial
. 2010 Jun;48(6):1031-2.
doi: 10.1016/j.yjmcc.2010.02.002. Epub 2010 Feb 6.

Cardiac spectrins: alternative splicing encodes functional diversity

Thomas J Hund, Peter J Mohler
Editorial

Cardiac spectrins: alternative splicing encodes functional diversity

Thomas J Hund et al. J Mol Cell Cardiol. 2010 Jun.
No abstract available

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Figures

Figure 1
Figure 1. Structure of αII-spectrin and location of cardi+ insert
αII-spectrin is comprised of 21 triple helical spectrin repeats and a C-terminal calmodulin-like domain. Binding to β-spectrin occurs in repeat 1. Repeat 10 contains an SH3 domain commonly found in cell signaling proteins. The newly identified cardi+ splice variant results in a 21 amino acid insert in repeat 21 that affects binding affinity for β-spectrin and may regulate cardiomyocyte growth [28].
See this image and copyright information in PMC

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References

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