doi: 10.1016/j.cub.2009.12.016.
Bacterial invasion: linking autophagy and innate immunity
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- PMID: 20144769
- DOI: 10.1016/j.cub.2009.12.016
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Bacterial invasion: linking autophagy and innate immunity
Curr Biol.
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Free article
Abstract
Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.
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