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. 2010 Feb 9;20(3):R106-8.
doi: 10.1016/j.cub.2009.12.016.

Bacterial invasion: linking autophagy and innate immunity

Lorenzo Galluzzi  1 , Oliver Kepp, Laurence Zitvogel, Guido Kroemer
Affiliations
Free article

Bacterial invasion: linking autophagy and innate immunity

Lorenzo Galluzzi et al. Curr Biol. .
Free article

Abstract

Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.

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