Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Apr;22(2):206-11.
doi: 10.1016/j.coi.2010.01.005. Epub 2010 Feb 9.

Regulation of plasmacytoid dendritic cell development

Boris Reizis  1
Affiliations
Review

Regulation of plasmacytoid dendritic cell development

Boris Reizis. Curr Opin Immunol. 2010 Apr.

Abstract

Plasmacytoid dendritic cells (PDC) represent a distinct immune cell type specialized in direct virus recognition and rapid secretion of type I interferon. The origin and lineage affiliation of PDC have been controversial, partly because PDC show features of both lymphocytes and dendritic cells (DC). Recent studies helped elucidate the cellular and molecular basis of PDC development. In particular, the common developmental origin and genetic similarity of PDC and classical antigen-presenting DC have been established. In addition, E protein transcription factor E2-2 was shown to control lineage commitment and gene expression program of PDC. Because E proteins are essential regulators of lymphocyte development, E2-2 activity may underlie the distinct 'lymphoid' features of PDC.

PubMed Disclaimer

Figures

Figure 1
Figure 1. E proteins and their targets in dendritic cells
Shown is the schematic composition of E protein complexes and their cognate E box sites (CANNTG) in B cells, immature T or B lymphocytes, cDC and PDC. The homodimeric E2-2 complex in PDC is inferred because E2a and HEB are dispensable for PDC development in vivo [26]. The proposed classes of E protein target genes in PDC are indicated, including PDC-specific, shared PDC/B cell-specific, and shared PDC/immature lymphocyte-specific targets.
See this image and copyright information in PMC

References

    1. Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol. 2004;5:1219–1226. - PubMed
    1. Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol. 2005;23:275–306. - PubMed
    1. Blasius AL, Colonna M. Sampling and signaling in plasmacytoid dendritic cells: the potential roles of Siglec-H. Trends Immunol. 2006;27:255–260. - PubMed
    1. Gilliet M, Cao W, Liu YJ. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol. 2008 - PubMed
    1. Tai LH, Goulet ML, Belanger S, Toyama-Sorimachi N, Fodil-Cornu N, Vidal SM, Troke AD, McVicar DW, Makrigiannis AP. Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC. J Exp Med. 2008;205:3187–3199. - PMC - PubMed

    2. • Murine Ly49Q, a C-type lectin-like receptor specific for MHC class I molecules, is expressed specifically on PDC. This study shows an essential role for this PDC-specific receptor in IFN secretion and antiviral immunity.

Publication types

MeSH terms

Substances