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Comment
. 2010 Feb 16;107(7):2731-2.
doi: 10.1073/pnas.0914721107. Epub 2010 Feb 9.

ASK-ing EMT not to spread cancer

Natasha Kyprianou  1
Affiliations
Comment

ASK-ing EMT not to spread cancer

Natasha Kyprianou. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
EMT regulation in prostate cancer cells. Loss of expression of E-cadherin, a key participant in calcium-dependent interactions which form epithelial adherent junctions, is the principal characteristic of EMT. In response to TGFβ1, Smad-mediated EMT proceeds via induction of Snail, Slug, and Twist, and Smad-independent phosphorylation of Par6 contributes to the dissolution of cell junction complexes via Smurf. Snail binds to E-cadherin promoter and represses its transcription during EMT. E-cadherin repressors induce EMT by regulating expression of genes repressing the epithelial character and promoting the mesenchymal state (AR). DAB12P controls epithelial cell movement and survival, stopping EMT. AJ, adherent junctions.
See this image and copyright information in PMC

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