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. 2010 Jul;105(7):1567-73.
doi: 10.1038/ajg.2010.18. Epub 2010 Feb 9.

Nonalcoholic fatty liver disease increases risk of death among patients with diabetes: a community-based cohort study

Leon A Adams  1 , Scott Harmsen, Jennifer L St Sauver, Phunchai Charatcharoenwitthaya, Felicity B Enders, Terry Therneau, Paul Angulo
Affiliations

Nonalcoholic fatty liver disease increases risk of death among patients with diabetes: a community-based cohort study

Leon A Adams et al. Am J Gastroenterol. 2010 Jul.

Abstract

Objectives: The significance of nonalcoholic fatty liver disease (NAFLD) among patients with diabetes is unknown. We sought to determine whether a diagnosis of NAFLD influenced mortality among a community-based cohort of patients with type II diabetes mellitus.

Methods: A total of 337 residents of Olmsted County, Minnesota with diabetes mellitus diagnosed between 1980 and 2000 were identified using the Rochester Epidemiology Project and the Mayo Laboratory Information System, and followed for 10.9 + or - 5.2 years (range 0.1-25). Survival was analyzed using Cox proportional hazards modeling, with NAFLD treated as a time-dependent covariate.

Results: Among the 337 residents, 116 were diagnosed with NAFLD 0.9 + or - 4.6 years after diabetes diagnosis. Patients with NAFLD were younger, and more likely to be female and obese. Overall, 99/337 (29%) patients died. In multivariate analysis to adjust for confounders, overall mortality was significantly associated with a diagnosis of NAFLD (hazard ratio (HR) 2.2; 95% confidence interval (CI) 1.1, 4.2; P=0.03), presence of ischemic heart disease (HR 2.3; 95% CI 1.2, 4.4), and duration of diabetes (HR per 1 year, 1.1; 95% CI 1.03, 1.2). The most common causes of death in the NAFLD cohort were malignancy (33% of deaths), liver-related complications (19% of deaths), and ischemic heart disease (19% of deaths). In adjusted multivariate models, NAFLD was borderline associated with an increased risk of dying from malignancy (HR 2.3; 95% CI 0.9, 5.9; P=0.09) and not from cardiovascular disease (HR 0.9; 95% CI 0.3, 2.4; P=0.81).

Conclusions: The diagnosis of NAFLD is associated with an increased risk of overall death among patients with diabetes mellitus.

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Conflict of interest statement

Conflict of Interest Items

  1. Which author is the guarantor of the manuscript?

    Leon Adams

  2. What was each author's contribution to the paper?

    Leon Adams contributed to study design, data collection and analysis and interpretation and manuscript writing.

    Scott Harmsen, Jennifer L. St.Sauver and Felicity B. Enders all contributed to the study design, data analysis and interpretation.

    Terry Therneau contributed to the data analysis and interpretation.

    Phunchai Charatcharoenwitthaya contributed to the data collection and manuscript preparation.

    Paul Angulo contributed to study design, data analysis and interpretation and manuscript writing.

  3. What financial support was given to the project?

    The study was supported by an R01 DK82426 to Dr Paul Angulo. Dr Leon Adams was sponsored by medical research scholarships from the National Health and Medical Research Council (No. 353710) and The University of Western Australia (Athelstan and Amy Saw Scholarship).

  4. What potential competing interests exist?

    None.

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