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Comment
. 2010 Mar;130(3):641-3.
doi: 10.1038/jid.2009.421.

Defining the antigen determinant for T-cell-mediated contact dermatitis using p-phenylenediamine: a gateway to chemical immunology

Graham Elliott  1 , Pranab Kumar Das
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Defining the antigen determinant for T-cell-mediated contact dermatitis using p-phenylenediamine: a gateway to chemical immunology

Graham Elliott et al. J Invest Dermatol. 2010 Mar.
Free article

Abstract

By binding to host proteins to form haptens, low-molecular-weight compounds such as p-phenylenediamine (PPD) can become contact sensitizers. In this issue, Jenkinson et al. demonstrate that it is possible to use chemically characterized hapten-protein complexes to analyze T-cell responses in cells from allergic individuals. This approach may help in the development of in vitro tests for diagnosing contact dermatitis.

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