Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Mar;130(3):648-50.
doi: 10.1038/jid.2009.291.

KIT masters mast cells in kids, too

Naotomo Kambe  1 , B Jack Longley, Yoshiki Miyachi, Kenji Kabashima
Affiliations
Free article
Comment

KIT masters mast cells in kids, too

Naotomo Kambe et al. J Invest Dermatol. 2010 Mar.
Free article

Abstract

Adult mastocytosis is usually persistent and caused by c-KIT codon 816-activating mutations. Pediatric mastocytosis is often transient, and the molecular mechanism driving mast cell proliferation in pediatric cases remains unclear. In this issue, Bodemer et al. report novel c-KIT mutations in a large percentage of pediatric cases, identifying both similarities and fundamental differences in the mechanisms causing adult and pediatric mastocytosis.

PubMed Disclaimer

Comment on

  • Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations.
    Bodemer C, Hermine O, Palmérini F, Yang Y, Grandpeix-Guyodo C, Leventhal PS, Hadj-Rabia S, Nasca L, Georgin-Lavialle S, Cohen-Akenine A, Launay JM, Barete S, Feger F, Arock M, Catteau B, Sans B, Stalder JF, Skowron F, Thomas L, Lorette G, Plantin P, Bordigoni P, Lortholary O, de Prost Y, Moussy A, Sobol H, Dubreuil P. Bodemer C, et al. J Invest Dermatol. 2010 Mar;130(3):804-15. doi: 10.1038/jid.2009.281. Epub 2009 Oct 29. J Invest Dermatol. 2010. PMID: 19865100

Substances

LinkOut - more resources