Influence of the use of statin on the stability of erythrocyte membranes in multiple sclerosis
- PMID: 20146058
- DOI: 10.1007/s00232-010-9232-y
Influence of the use of statin on the stability of erythrocyte membranes in multiple sclerosis
Abstract
Multiple sclerosis (MS) probably occurs by oxidative, inflammatory and autoimmune mechanisms. This study investigated the influence of statin on the stability of erythrocyte membranes in MS patients. The population was composed of one group with simvastatin therapy (20 mg/day), another group without statin therapy and a healthy control group. The stability of erythrocytes was evaluated by the half-transition points, H(50) and D(50), obtained from the curves of hemolysis induced by hypotonic shock and ethanol action, respectively. Erythrocytes of MS patients were less stable against lysis by both chaotropes. This behavior may be merely a consequence of the lifestyle of MS patients or it may be intrinsically associated with the conjunct of factors responsible for the development of the disease. The use of statin by MS patients was associated with lower levels of LDL and total cholesterol, as expected, and with higher stability of erythrocytes against ethanol compared to the values of untreated MS patients.
Similar articles
-
The effect of simvastatin on erythrocyte membrane fluidity during oxidative stress induced by cardiopulmonary bypass: a randomized controlled study.Clin Ther. 2007 Aug;29(8):1706-17. doi: 10.1016/j.clinthera.2007.08.010. Clin Ther. 2007. PMID: 17919551 Clinical Trial.
-
Physicochemical modifications induced by statins therapy on human erythrocytes membranes.Wiad Lek. 2007;60(7-8):321-8. Wiad Lek. 2007. PMID: 18175550 Clinical Trial.
-
Evaluation of atorvastatin and simvastatin for treatment of multiple sclerosis.Expert Rev Neurother. 2007 May;7(5):547-56. doi: 10.1586/14737175.7.5.547. Expert Rev Neurother. 2007. PMID: 17492904 Review.
-
Simvastatin Therapy in Multiple Sclerosis Patients with Respect to Gut Microbiome-Friend or Foe?J Neuroimmune Pharmacol. 2019 Dec;14(4):531-533. doi: 10.1007/s11481-019-09881-y. Epub 2019 Oct 18. J Neuroimmune Pharmacol. 2019. PMID: 31628587 No abstract available.
-
Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response.Immunol Res. 2008;41(3):165-74. doi: 10.1007/s12026-008-8019-z. Immunol Res. 2008. PMID: 18484192 Review.
Cited by
-
Influence of the albumin concentration and temperature on the lysis of human erythrocytes by sodium dodecyl sulfate.J Bioenerg Biomembr. 2010 Oct;42(5):413-8. doi: 10.1007/s10863-010-9310-y. Epub 2010 Sep 21. J Bioenerg Biomembr. 2010. PMID: 20857184
-
Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population.J Lipid Res. 2013 Nov;54(11):3177-88. doi: 10.1194/jlr.P037614. Epub 2013 Sep 2. J Lipid Res. 2013. PMID: 23999863 Free PMC article.
-
Oxidative Stress and Neurobiology of Demyelination.Mol Neurobiol. 2016 Jan;53(1):744-758. doi: 10.1007/s12035-014-9041-x. Epub 2014 Dec 11. Mol Neurobiol. 2016. PMID: 25502298 Review.
-
Effects of acute and chronic exercise on the osmotic stability of erythrocyte membrane of competitive swimmers.PLoS One. 2017 Feb 2;12(2):e0171318. doi: 10.1371/journal.pone.0171318. eCollection 2017. PLoS One. 2017. PMID: 28151958 Free PMC article.
-
Effect of Whole-Body Cryotherapy on Morphological, Rheological and Biochemical Indices of Blood in People with Multiple Sclerosis.J Clin Med. 2021 Jun 27;10(13):2833. doi: 10.3390/jcm10132833. J Clin Med. 2021. PMID: 34198961 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical