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. 1991 Apr;181(2):764-7.
doi: 10.1016/0042-6822(91)90914-w.

Proteolysis at the 2A/2B junction in Theiler's murine encephalomyelitis virus

S Batson  1 , K Rundell
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Proteolysis at the 2A/2B junction in Theiler's murine encephalomyelitis virus

S Batson et al. Virology. 1991 Apr.

Abstract

Processing at the 2A/2B junction in Theiler's murine encephalomyelitis virus (TMEV) was studied using in vitro transcription and translation. A plasmid which contained only the P2 region of TMEV was used. The protein products obtained after in vitro transcription/translation indicated that proteolysis at the 2A/2B junction occurs even if templates coding for only the 2A and 2B proteins are used. Time-course experiments indicated that 2A/2B proteolysis was cotranslational. The plasmid described will allow further definition of the sequences involved in this proteolytic event.

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