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Comment
. 2010 Feb 11;463(7282):E6-7.
doi: 10.1038/nature08751.

Chronic DLL4 blockade induces vascular neoplasms

Minhong Yan  1 , Christopher A Callahan, Joseph C Beyer, Krishna P Allamneni, Gu Zhang, John Brady Ridgway, Kyle Niessen, Greg D Plowman
Affiliations
Comment

Chronic DLL4 blockade induces vascular neoplasms

Minhong Yan et al. Nature. .

Abstract

Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.

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