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. 2010:2010:218691.
doi: 10.1155/2010/218691. Epub 2010 Jan 28.

Vitamin d deficiency in cystic fibrosis

William B Hall  1 , Amy A Sparks, Robert M Aris
Affiliations

Vitamin d deficiency in cystic fibrosis

William B Hall et al. Int J Endocrinol. 2010.

Abstract

Cystic Fibrosis is the most common inherited genetic respiratory disorder in the Western World. Hypovitaminosis D is almost universal in CF patients, likely due to a combination of inadequate absorption, impaired metabolism, and lack of sun exposure. Inadequate levels are associated with the high prevalence of bone disease or osteoporosis in CF patients, which is associated with increased morbidity including fractures, kyphosis, and worsening pulmonary status. Treatment goals include regular monitoring 25 hydroxyvitamin D (25OHD) levels with aggressive treatment for those with levels <75 nmol/L (<30 ng/mL). More research is needed to determine optimal supplementation goals and strategies.

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Figures

Figure 1
Figure 1
Causes of Vitamin D insufficiency in CF Patients [11].
Figure 2
Figure 2
Impaired absorption of Vitamin D following a 2500 ug dose in in CF patients and controls [13].
Figure 3
Figure 3
Suggested Vitamin D supplementation algorithm.
See this image and copyright information in PMC

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