Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jun;21(6):897-908.
doi: 10.1007/s10552-010-9518-5. Epub 2010 Feb 11.

Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women

Jennifer Lin  1 , Robert Y L Zee, Kuang-Yu Liu, Shumin M Zhang, I-Min Lee, JoAnn E Manson, Edward Giovannucci, Julie E Buring, Nancy R Cook
Affiliations

Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women

Jennifer Lin et al. Cancer Causes Control. 2010 Jun.

Abstract

Objectives: Several lines of evidence have suggested that female hormones may lower the risk for developing colorectal cancer. However, the mechanisms by which sex hormones affect colorectal cancer development remain unknown. We sought to determine whether the association may be under genetic control by evaluating genetic variation in estrogen receptors (ESR1 and ESR2), progesterone receptor (PGR), aromatase cytochrome 450 enzyme (CYP19A1), and 17 beta-hydroxysteroid dehydrogenase type 2 gene (HSD17B2).

Methods: We included 158 incident cases of colorectal cancer and 563 randomly chosen control subjects from 28,345 women in the Women's Health Study aged 45 or older who provided blood samples and had no history of cancer or cardiovascular disease at baseline in 1993. All cases and controls were Caucasians of European descent. A total of 63 tagging and putative functional SNPs in the 5 genes were included for analysis. Unconditional logistic regression was used to estimate odds ratio (ORs) and 95% confidence intervals (CIs).

Results: There was no association between variation in ESR1, ESR2, PGR, CYP19A1 and HSD17B2 and colorectal cancer risk after correction for multiple comparisons (p values after correction > or =0.25). There was also no association with any of the haplotypes examined (p > or = 0.15) and no evidence of joint effects of variants in the 5 genes (p > or = 0.51).

Conclusion: Our data offer insufficient support for an association between variation in ESR1, ESR2, PGR, CYP19A1, and HSD17B2 and risk for developing colorectal cancer.

PubMed Disclaimer

References

    1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008 Mar-Apr;58(2):71–96. - PubMed
    1. Froggatt NJ, Green J, Brassett C, Evans DG, Bishop DT, Kolodner R, et al. A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer. J Med Genet. 1999 Feb;36(2):97–102. - PMC - PubMed
    1. Ochiai M, Watanabe M, Kushida H, Wakabayashi K, Sugimura T, Nagao M. DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis. Carcinogenesis. 1996 Jan;17(1):95–8. - PubMed
    1. Odagiri E, Jibiki K, Kato Y, Nakamura S, Oda S, Demura R, et al. Steroid receptors in dimethylhydrazine-induced colon carcinogenesis. Cancer. 1985 Dec 1;56(11):2627–34. - PubMed
    1. Gershbein LL. Action of estrogen and adrenocorticoids on adenocarcinoma induction by 1,2-dimethylhydrazine in male rats. Res Commun Chem Pathol Pharmacol. 1993 Jul;81(1):117–20. - PubMed

Publication types

LinkOut - more resources