doi: 10.1021/ol1000999.
Novel and efficient chiral bisphosphorus ligands for rhodium-catalyzed asymmetric hydrogenation
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- PMID: 20148522
- DOI: 10.1021/ol1000999
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Novel and efficient chiral bisphosphorus ligands for rhodium-catalyzed asymmetric hydrogenation
Org Lett.
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Abstract
A series of structurally novel, operationally convenient, and efficient chiral 2-phosphino-2,3-dihydrobenzo[d][1,3]oxaphosphole ligands was developed. Applications of ligands 3a and 3b in rhodium-catalyzed asymmetric hydrogenation of alpha-(acylamino)acrylates and beta-(acylamino)acrylates provided excellent enantioselectivities (up to >99% ee) and reactivities (up to 10,000 TON).
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