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. 2010 Mar 5;12(5):1104-7.
doi: 10.1021/ol1000999.

Novel and efficient chiral bisphosphorus ligands for rhodium-catalyzed asymmetric hydrogenation

Wenjun Tang  1 , Andrew G Capacci, Andre White, Shengli Ma, Sonia Rodriguez, Bo Qu, Jolaine Savoie, Nitinchandra D Patel, Xudong Wei, Nizar Haddad, Nelu Grinberg, Nathan K Yee, Dhileepkumar Krishnamurthy, Chris H Senanayake
Affiliations

Novel and efficient chiral bisphosphorus ligands for rhodium-catalyzed asymmetric hydrogenation

Wenjun Tang et al. Org Lett. .

Abstract

A series of structurally novel, operationally convenient, and efficient chiral 2-phosphino-2,3-dihydrobenzo[d][1,3]oxaphosphole ligands was developed. Applications of ligands 3a and 3b in rhodium-catalyzed asymmetric hydrogenation of alpha-(acylamino)acrylates and beta-(acylamino)acrylates provided excellent enantioselectivities (up to >99% ee) and reactivities (up to 10,000 TON).

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