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. 2010 Feb;12(1):102-6.
doi: 10.1111/j.1399-5618.2009.00771.x.

Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1

Ting Ting Chang  1 , Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Hsiang Yu Huang, Yen Kuang Yang, I Hui Lee, Ru Band Lu
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Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1

Ting Ting Chang et al. Bipolar Disord. 2010 Feb.

Abstract

Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients.

Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1.

Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT.

Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.

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