Amyloid oligomers: formation and toxicity of Abeta oligomers

Abstract

Alzheimer's disease (AD) is an age-related, progressive degenerative disorder that is characterized by synapse and neuron loss in the brain and the accumulation of protein-containing deposits (referred to as 'senile plaques') and neurofibrillary tangles. Insoluble amyloid beta-peptide (Abeta) fibrillar aggregates found in extracellular plaques have long been thought to cause the neurodegenerative cascades of AD. However, accumulating evidence suggests that prefibrillar soluble Abeta oligomers induce AD-related synaptic dysfunction. The size of Abeta oligomers is distributed over a wide molecular weight range (from < 10 kDa to > 100 kDa), with structural polymorphism in Abeta oligomers of similar sizes. Recent studies have demonstrated that Abeta can accumulate in living cells, as well as in extracellular spaces. This review summarizes current research on Abeta oligomers, focusing on their structures and toxicity mechanism. We also discuss possible formation mechanisms of intracellular and extracellular Abeta oligomers.