doi: 10.1016/j.ejmech.2010.01.046.
Epub 2010 Jan 28.
Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates
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- PMID: 20149497
- DOI: 10.1016/j.ejmech.2010.01.046
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Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates
Eur J Med Chem.
2010 May.
Abstract
As part of an ongoing project to develop highly potent anti-tuberculosis therapeutics, six SQ109 derivatives were synthesized and screened in vitro for their anti-tuberculosis activity against the ATCC strain H37Rv and the extensively drug-resistant clinical strain XDR 173. Compound 16 with an extended alkene chain was the most active against both strains of Mycobacterium tuberculosis within a MIC range of 0.5-0.25 microM. Compound 12 and SQ109 were potent within a MIC range of 1-0.5 microM, whilst compound 18 displayed an activity within the MIC range of 0.5-2 microM against both Mycobacterium tuberculosis strains.
Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
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