Review
doi: 10.1016/j.drudis.2010.02.001.
Epub 2010 Feb 10.
Stem cell therapies for ocular surface disease
Affiliations
- PMID: 20149892
- DOI: 10.1016/j.drudis.2010.02.001
Item in Clipboard
Review
Stem cell therapies for ocular surface disease
Drug Discov Today.
2010 Apr.
Abstract
Transparency of the cornea on the front surface of the eye is essential for vision. A variety of blinding ocular surface diseases involve the cornea. This review focusses on vision loss caused by disruption of the integrity and function of the outermost corneal layer (the epithelium) and the stem-cell-based therapeutic strategies in use and under development to restore sight in affected patients.
2010 Elsevier Ltd. All rights reserved.
Similar articles
-
Ex vivo expansion of corneal limbal epithelial/stem cells for corneal surface reconstruction.Eur J Ophthalmol. 2003 Jul;13(6):515-24. doi: 10.1177/112067210301300602. Eur J Ophthalmol. 2003. PMID: 12948308 Review.
-
[Limbal epithelial stem cell transplantation : Current state and perspectives].Ophthalmologe. 2017 Apr;114(4):298-306. doi: 10.1007/s00347-017-0462-6. Ophthalmologe. 2017. PMID: 28239777 German.
-
Limbal epithelial cell therapy: past, present, and future.Methods Mol Biol. 2013;1014:3-43. doi: 10.1007/978-1-62703-432-6_1. Methods Mol Biol. 2013. PMID: 23690002 Review.
-
The limbal epithelium of the eye--a review of limbal stem cell biology, disease and treatment.Bioessays. 2013 Mar;35(3):211-9. doi: 10.1002/bies.201200086. Epub 2012 Nov 5. Bioessays. 2013. PMID: 23129317 Review.
-
Pluripotent Stem Cells and Other Innovative Strategies for the Treatment of Ocular Surface Diseases.Stem Cell Rev Rep. 2016 Apr;12(2):171-8. doi: 10.1007/s12015-016-9643-y. Stem Cell Rev Rep. 2016. PMID: 26779895 Review.
Cited by
-
Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human corneal limbus.Sci Rep. 2017 Jun 14;7(1):3448. doi: 10.1038/s41598-017-03449-7. Sci Rep. 2017. PMID: 28615632 Free PMC article.
-
Gelatin-Based Materials in Ocular Tissue Engineering.Materials (Basel). 2014 Apr 17;7(4):3106-3135. doi: 10.3390/ma7043106. Materials (Basel). 2014. PMID: 28788609 Free PMC article. Review.
-
Tissue-regenerating, vision-restoring corneal epithelial stem cells.Stem Cell Rev Rep. 2011 Jun;7(2):256-68. doi: 10.1007/s12015-010-9199-1. Stem Cell Rev Rep. 2011. PMID: 21069583 Review.
-
Biofabrication of Artificial Stem Cell Niches in the Anterior Ocular Segment.Bioengineering (Basel). 2021 Sep 30;8(10):135. doi: 10.3390/bioengineering8100135. Bioengineering (Basel). 2021. PMID: 34677208 Free PMC article. Review.
-
NRG1 Regulates Proliferation, Migration and Differentiation of Human Limbal Epithelial Stem Cells.Curr Issues Mol Biol. 2023 Dec 14;45(12):10121-10130. doi: 10.3390/cimb45120632. Curr Issues Mol Biol. 2023. PMID: 38132478 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
