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. 2010 Jan;12(1):2-6.
doi: 10.1093/neuonc/nop002. Epub 2009 Oct 15.

Chromosome 9p and 10q losses predict unfavorable outcome in low-grade gliomas

Caroline Houillier  1 , Karima Mokhtari, Catherine Carpentier, Emmanuelle Crinière, Yannick Marie, Audrey Rousseau, Gentian Kaloshi, Caroline Dehais, Julien Laffaire, Florence Laigle-Donadey, Khê Hoang-Xuan, Marc Sanson, Jean-Yves Delattre
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Chromosome 9p and 10q losses predict unfavorable outcome in low-grade gliomas

Caroline Houillier et al. Neuro Oncol. 2010 Jan.

Abstract

The loss of chromosomes 1p-19q is the only prognostic molecular alteration identified in low-grade gliomas (LGGs) to date. Search for loss of heterozygosity (LOH) on chromosomes 1p, 9p, 10q, and 19q was performed in a series of 231 LGGs. Loss of chromosomes 1p-19q was strongly correlated with prolonged progression-free survival (PFS) and overall survival (OS) in univariate and multivariate analyses. LOH on 9p and 10q were associated with shortened PFS (P = .01 and .03, respectively) on univariate analysis. On multivariate analysis, LOH on 9p remained significant for PFS (P = .05), whereas LOH on 10q had a significant effect on OS (P = .02). Search for LOH 9p and 10q appears to be a useful complement to analysis of chromosomes 1p-19q in LGGs.

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Figures

Fig. 1.
Fig. 1.
The prognostic advantage conferred by deletion of chromosomes 1p–19q on PFS is lost in patients with combined chromosome 9p loss.
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