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Multicenter Study
. 2010 Apr;95(4):1786-92.
doi: 10.1210/jc.2009-2106. Epub 2010 Feb 11.

Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism

Alice S Park  1 , Mark A Lawson, Sandy S Chuan, Sharon E Oberfield, Kathleen M Hoeger, Selma F Witchel, R Jeffrey Chang
Affiliations
Multicenter Study

Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism

Alice S Park et al. J Clin Endocrinol Metab. 2010 Apr.

Abstract

Context: Serum anti-Müllerian hormone (AMH) levels are significantly elevated in adolescents with polycystic ovary syndrome (PCOS) compared to normal controls. Whether adolescents with oligomenorrhea have elevated AMH levels is unknown.

Objective: This study was performed to assess serum AMH levels in oligomenorrheic (OLIGO) girls without evidence of hyperandrogenism.

Design: This was a prospective study comparing AMH levels in OLIGO, PCOS, and normal control adolescents.

Setting: The study was conducted through four tertiary academic medical centers.

Participants: The study groups were comprised of OLIGO (n = 24), PCOS (n = 153), and normal adolescent girls (n = 39), as well as PCOS (n = 73) and normal adult women (n = 36).

Interventions: In each subject, serum AMH levels were assessed in the early to midfollicular phases for regularly menstruating subjects and on an arbitrary day for OLIGO or PCOS subjects.

Main outcome measure(s): Basal serum AMH levels were assessed among OLIGO, PCOS, and normal girls, in addition to PCOS and normal women.

Results: OLIGO girls had serum AMH levels (5.33 +/- 0.47 ng/ml) that were significantly greater than the normal adolescents (3.05 +/- 0.31 ng/ml) and adults (2.33 +/- 0.22 ng/ml), but similar to values seen in the PCOS adolescents (5.28 +/- 0.26 ng/ml) and adults (6.36 +/- 0.47 ng/ml). Obese adolescents and PCOS women had significantly lower AMH levels compared to lean controls (P < 0.02).

Conclusion: In OLIGO adolescents, elevated serum AMH levels suggest increased antral follicle number similar to that observed in girls with PCOS.

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Figures

Figure 1
Figure 1
Comparison of serum AMH levels among NC, OLIGO, and PCOS adolescents, and normal and PCOS adults. AMH values in OLIGO and both PCOS groups were similar. In each of these groups, mean serum AMH was greater than that observed in either adolescent or adult NC (P < 0.001). There was no significant difference between the NC groups. *, Significantly different from NC adolescent (P < 0.001).
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