Review
doi: 10.4161/epi.5.2.11080.
Epub 2010 Mar 1.
GammaH2AX as a molecular marker of aging and disease
Affiliations
- PMID: 20150765
- DOI: 10.4161/epi.5.2.11080
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Review
GammaH2AX as a molecular marker of aging and disease
Epigenetics.
.
Free article
Abstract
Double-strand breaks are one of the most critical DNA lesions with respect to cell-death and preservation of genomic integrity. Rapid phosphorylation of the histone variant H2AX at Ser-139 to form gammaH2AX is an early cellular response to DNA double-strand breaks. Visualization of discrete gammaH2AX foci using immunofluorescence-based assays has provided a sensitive and effective method for detecting DSBs which may be implicated in various pathologies including cancer, age-related diseases, chronic inflammatory diseases and ischemia-reperfusion injury. In this review, the potential utility and significance of gammaH2AX as a molecular marker of aging and disease is analysed.
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