Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Apr;2(4):525.
doi: 10.1517/17460441.2.4.525.

Potential of phage-displayed peptide library technology to identify functional targeting peptides

Lauren Rh Krumpe  1 , Toshiyuki Mori
Affiliations

Potential of phage-displayed peptide library technology to identify functional targeting peptides

Lauren Rh Krumpe et al. Expert Opin Drug Discov. 2007 Apr.

Abstract

Combinatorial peptide library technology is a valuable resource for drug discovery and development. Several peptide drugs developed through phage-displayed peptide library technology are presently in clinical trials and the authors envision that phage-displayed peptide library technology will assist in the discovery and development of many more. This review attempts to compile and summarize recent literature on targeting peptides developed through peptide library technology, with special emphasis on novel peptides with targeting capacity evaluated in vivo.

Keywords: library; peptide; phage display; targeting.

PubMed Disclaimer

References

    1. Krumpe LR, Mori T. The use of phage-displayed peptide libraries to develop tumor-targeting drugs. Int J Peptide Res Ther. 2006;12(1):79–91. - PMC - PubMed
    1. Mori T. Cancer-specific ligands identified from screening of peptide-display libraries. Curr Pharm Des. 2004;10(19):2335–2343. - PubMed
    1. Brissette R, Prendergast JK, Goldstein NI. Identification of cancer targets and therapeutics using phage display. Curr Opin Drug Discov Dev. 2006;9(3):363–369. - PubMed
    1. Rowley MJ, O'Connor K, Wijeyewickrema L. Phage display for epitope determination: a paradigm for identifying receptor–ligand interactions. Biotechnol Ann Rev. 2004;10:151–188. - PubMed
    1. Mullen LM, Nair SP, Ward JM, Rycroft AN, Henderson B. Phage display in the study of infectious diseases. Trends Microbiol. 2006;14(3):141–147. - PMC - PubMed

LinkOut - more resources