doi: 10.1186/2040-7378-1-7.
Animal models of focal brain ischemia
Affiliations
- PMID: 20150985
- PMCID: PMC2820445
- DOI: 10.1186/2040-7378-1-7
Item in Clipboard
Animal models of focal brain ischemia
Exp Transl Stroke Med.
.
Abstract
Stroke is a leading cause of disability and death in many countries. Understanding the pathophysiology of ischemic injury and developing therapies is an important endeavor that requires much additional research. Animal stroke models provide an important mechanism for these activities. A large number of stroke models have been developed and are currently used in laboratories around the world. These models are overviewed as are approaches for measuring infarct size and functional outcome.
Similar articles
-
Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke.Stroke. 2003 Aug;34(8):e109-37. doi: 10.1161/01.STR.0000082721.62796.09. Epub 2003 Jul 17. Stroke. 2003. PMID: 12869717
-
Post-stroke gastrodin treatment ameliorates ischemic injury and increases neurogenesis and restores the Wnt/β-Catenin signaling in focal cerebral ischemia in mice.Brain Res. 2019 Jun 1;1712:7-15. doi: 10.1016/j.brainres.2019.01.043. Epub 2019 Feb 1. Brain Res. 2019. PMID: 30716287
-
Revealing the Penumbra through Imaging Elemental Markers of Cellular Metabolism in an Ischemic Stroke Model.ACS Chem Neurosci. 2018 May 16;9(5):886-893. doi: 10.1021/acschemneuro.7b00382. Epub 2018 Jan 30. ACS Chem Neurosci. 2018. PMID: 29370523
-
Animal models of focal and global cerebral ischemia.ILAR J. 2003;44(2):85-95. doi: 10.1093/ilar.44.2.85. ILAR J. 2003. PMID: 12652003 Review.
-
Models of focal cerebral ischemia in the nonhuman primate.ILAR J. 2003;44(2):96-104. doi: 10.1093/ilar.44.2.96. ILAR J. 2003. PMID: 12652004 Review.
Cited by
-
Are Underlying Assumptions of Current Animal Models of Human Stroke Correct: from STAIRs to High Hurdles?Transl Stroke Res. 2011 Jun;2(2):138-43. doi: 10.1007/s12975-011-0067-3. Epub 2011 Feb 12. Transl Stroke Res. 2011. PMID: 21654913 Free PMC article.
-
Continuous Glibenclamide Prevents Hemorrhagic Transformation in a Rodent Model of Severe Ischemia-Reperfusion.J Stroke Cerebrovasc Dis. 2021 Mar;30(3):105595. doi: 10.1016/j.jstrokecerebrovasdis.2020.105595. Epub 2021 Jan 12. J Stroke Cerebrovasc Dis. 2021. PMID: 33450605 Free PMC article.
-
Neuroprotective effects of human umbilical cord mesenchymal stem cells (Neuroncell-EX) in a rat model of ischemic stroke are mediated by immunomodulation, blood-brain barrier integrity, angiogenesis, and neurogenesis.In Vitro Cell Dev Biol Anim. 2025 Apr;61(4):389-402. doi: 10.1007/s11626-025-01037-y. Epub 2025 May 13. In Vitro Cell Dev Biol Anim. 2025. PMID: 40360812 Free PMC article.
-
A surgical model of permanent and transient middle cerebral artery stroke in the sheep.PLoS One. 2012;7(7):e42157. doi: 10.1371/journal.pone.0042157. Epub 2012 Jul 27. PLoS One. 2012. PMID: 22848737 Free PMC article.
-
PI3K/Akt Pathway Contributes to Neurovascular Unit Protection of Xiao-Xu-Ming Decoction against Focal Cerebral Ischemia and Reperfusion Injury in Rats.Evid Based Complement Alternat Med. 2013;2013:459467. doi: 10.1155/2013/459467. Epub 2013 May 28. Evid Based Complement Alternat Med. 2013. PMID: 23781261 Free PMC article.
References
-
- Bonita R. In: Stroke Prevention. Norris JW, Hachinksi V, editor. New York: Oxford University Press; 2001. Stroke prevention: global perspective; pp. 259–274.
-
- Sacco RL, Wolf PA, Gorelick PB. Risk factors and their management for stroke prevention: outlook for 1999 and beyond. Neurology. 1999;53:S15–S24. - PubMed
-
- Kaste M, Fogelholm R, Rissanen A. Economic burden of stroke and the evaluation of new therapies. Public Health. 1998;112:103–112. - PubMed
-
- Sacco RL, Boden-Albala B. In: Stroke Therapy. 2. Fisher M, editor. Woburn, MA: Butterworth-Heinemann; 2001. Stroke risk factors: identification and modification; pp. 1–24.
LinkOut - more resources
Full Text Sources
Other Literature Sources
