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. 1991 Jan;31(1):73-6.
doi: 10.1111/j.1365-2125.1991.tb03859.x.

Metabolism of almitrine in extensive and poor metabolisers of debrisoquine/sparteine

A Herchuelz  1 , D Gangji, F Derenne, J P Jeanniot, J Douchamps
Affiliations

Metabolism of almitrine in extensive and poor metabolisers of debrisoquine/sparteine

A Herchuelz et al. Br J Clin Pharmacol. 1991 Jan.

Abstract

1. Almitrine bismesylate displays wide inter-subject variation in peak plasma concentrations and can induce peripheral polyneuropathy. 2. The phenotyped volunteer panel approach was used to examine whether almitrine oxidation displayed a genetic polymorphism of the debrisoquine/sparteine type. 3. There was no difference between poor and extensive metabolisers of debrisoquine with respect to the pharmacokinetics and metabolism of almitrine.

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