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Review
. 2010 Jan 28;65(2):145-7.
doi: 10.1016/j.neuron.2010.01.010.

Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease

Michael S Levine  1 , Carlos Cepeda, Véronique M André
Affiliations
Review

Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease

Michael S Levine et al. Neuron. .

Abstract

Abnormally enhanced N-methyl-D-aspartate (NMDA) receptor function is implicated in Huntington's disease (HD). In this issue of Neuron and a recent issue of Nature Medicine, an abnormal balance between the activity of NMDA receptors at synaptic (prosurvival) and extrasynaptic (proapoptotic) sites has been uncovered in a cellular and a mouse model of HD.

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Figures

Fig. 1
Fig. 1
Synaptic and extrasynaptic receptors in HD. The left side shows synaptic and extrasynaptic NMDA receptors functioning in a balanced manner in the normal condition. On the right in HD there is an increase in extrasynaptic NMDA receptor function due to increase in either the number of receptors and/or an increase in extracellular glutamate that shifts the functional balance toward the extrasynaptic receptors enhancing the proapoptotic pathway.
See this image and copyright information in PMC

Comment on

References

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