Review
doi: 10.1016/j.immuni.2010.01.005.
Why CD8+ T cells need diversity when growing up
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- PMID: 20152164
- DOI: 10.1016/j.immuni.2010.01.005
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Review
Why CD8+ T cells need diversity when growing up
Immunity.
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Abstract
A thymus-specific subunit of the proteasome, beta5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that beta5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.
Copyright 2010 Elsevier Inc. All rights reserved.
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