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Review
. 2010 Jan 29;32(1):5-6.
doi: 10.1016/j.immuni.2010.01.005.

Why CD8+ T cells need diversity when growing up

Kristin A Hogquist  1 , Yan Xing
Affiliations
Free article
Review

Why CD8+ T cells need diversity when growing up

Kristin A Hogquist et al. Immunity. .
Free article

Abstract

A thymus-specific subunit of the proteasome, beta5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that beta5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.

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