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. 2010 Jun;210(2):656-61.
doi: 10.1016/j.atherosclerosis.2010.01.007. Epub 2010 Jan 21.

Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham Heart Study

Sam J Lehman  1 , Joseph M Massaro, Christopher L Schlett, Christopher J O'Donnell, Udo Hoffmann, Caroline S Fox
Affiliations

Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham Heart Study

Sam J Lehman et al. Atherosclerosis. 2010 Jun.

Abstract

Objective: Perivascular fat through the secretion of paracrine and pro-inflammatory mediators may play a role in obesity-mediated vascular disease. We sought to examine associations between adipose tissue depots immediately surrounding the thoracic aorta, metabolic risk factors, and vascular calcification.

Methods: In participants free of cardiovascular disease (CVD) from the Framingham Heart Study Offspring cohort who underwent computed tomography (n=1067, mean age 59 years, 56.1% women), thoracic peri-aortic fat depots were quantified. Visceral abdominal tissue (VAT) and calcification of the thoracic and abdominal aorta were also measured.

Results: Peri-aortic fat depots were correlated with body mass index, waist circumference (WC), VAT (all p<0.0001), hypertension (p=0.007), low HDL (p<0.0001), serum triglycerides (p<0.0001), impaired fasting glucose (p=0.005), and diabetes (p=0.02). These associations generally remained significant after adjustment for BMI and WC (all p-values<0.05), but not after VAT adjustment. Thoracic aortic fat was associated with thoracic calcification in models containing VAT (OR 1.31, 95% CI 1.01-1.71, p=0.04), but was not significant after adjustment for CVD risk factors (OR 1.16, 95% CI 0.88-1.51, p=0.30). Thoracic aortic fat, however, was associated with abdominal aortic calcification (OR 1.48, 95% CI 1.11-1.98, p=0.008) and coronary artery calcification (OR 1.47, 95% CI 1.09-1.98, p=0.001) even in models including CVD risk factors and VAT.

Conclusions: Thoracic peri-aortic fat is associated with measures of adiposity, metabolic risk factors, and coronary and abdominal aortic calcification.

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Conflict of interest statement

Disclosures

Dr. Fox, Hoffmann, Schlett and Lehman conceived the study, performed analysis, drafted and revised the manuscript. Dr. Massaro performed analysis, drafted and revised the manuscript. Dr. O’Donnell provided critical revisions to the manuscript and analysis. All authors have approved the manuscript as written. There are no conflicts of interest to disclose. Drs. Fox and Lehman had full access to the data, and take responsibility for its integrity.

References

    1. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, Vasan RS, Murabito JM, Meigs JB, Cupples LA, D’Agostino RB, Sr., O’Donnell CJ. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116:39–48. - PubMed
    1. Goodpaster BH, Krishnaswami S, Resnick H, Kelley DE, Haggert C, Harris TB, Schwartz AV, Kritchevsky S, Newman AB. Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care. 2003;26:372–379. - PubMed
    1. Chatterjee TK, Stoll LL, Denning GM, Harrelson A, Blomkalns AL, Idelman G, Rothenberg FG, Naltner B, Romig-Martin SA, Dickson EW, Rudich S, Weintraub NL. Proinflammatory phenyotype of perivascular adipocytes: influence of high-fat feeding. Circ Res. 2009;104:541–549. - PMC - PubMed
    1. Lemieux S, Prud'homme D, Moorjani S, Tremblay A, Bouchard C, Lupien PJ, Despres JP. Do elevated levels of abdominal visceral adipose tissue contribute to age-related differences in plasma lipoprotein concentrations in men? Atherosclerosis. 1995;118:155–164. - PubMed
    1. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, O’Donnell CJ, Fox CS. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors and vascular calcification in a community-based sample: the Framingham heart study. Circulation. 2008;117:605–613. - PubMed

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