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. 2010 May;104(5):357-63.
doi: 10.1016/j.trstmh.2010.01.009. Epub 2010 Feb 12.

Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children

Doa'a A Saleh  1 , Fatma M Shebl, Samer S El-Kamary, Laurence S Magder, Alif Allam, Mohamed Abdel-Hamid, Nabiel Mikhail, Mohamed Hashem, Soraya Sharaf, Sonia K Stoszek, G Thomas Strickland
Affiliations

Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children

Doa'a A Saleh et al. Trans R Soc Trop Med Hyg. 2010 May.

Abstract

A prospective study in three Egyptian villages (A, B and C) having a high prevalence of hepatitis C virus (HCV) infection examined incidence of community-acquired HCV infection in children; 2852 uninfected infants were prospectively followed from birth for up to 5.5 years. Fifteen seroconverted for either HCV antibodies and/or HCV-RNA (incidence of 0.53%). Ten had both anti-HCV and HCV-RNA; four had only anti-HCV; and one had HCV-RNA in the absence of antibody. The incidence rate at all ages was 2.7/1000 person-years (PY). It was 3.8/1000 PY during infancy and 2.0/1000 PY for the 1-5-years age group. Hospitalization and low birth weight increased the risk of infection; while living in village B, the family having a higher socioeconomic status, and advanced maternal education were protective. Six of eight HCV-infected infants reported iatrogenic exposures (e.g. hospitalization, therapeutic injections, ear piercing) prior to infection whereas only 2/7 children older than 1 year reported these exposures. Having an HCV-positive mother was the only other reported risk in two of these older children. The virus cleared in six (40%) children by the end of follow-up. Health education targeting iatrogenic exposures and focusing on risk factors could reduce HCV infection in children in high-risk populations.

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Conflict of interest statement

Conflicts of interest: None declared.

Figures

Figure 1
Figure 1
Incidence of hepatitis C virus (HCV) infection in children correlated with prevalence and incidence in women in three study villages in Menoufia Governorate, Egypt. Maternal HCV prevalence data adapted from Stoszek et al. and maternal HCV incidence data adapted from Saleh et al. IR/1000PY: incidence rate per 1000 person-years.
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