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. 2010 Mar 15;20(6):2013-6.
doi: 10.1016/j.bmcl.2010.01.090. Epub 2010 Jan 25.

The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure

Ian P Holmes  1 , Richard J Blunt, Olivier E Lorthioir, Stephen M Blowers, Andy Gribble, Andrew H Payne, Ian G Stansfield, Martyn Wood, Patrick M Woollard, Charlie Reavill, Claire M Howes, Fabrizio Micheli, Romano Di Fabio, Daniele Donati, Silvia Terreni, Dieter Hamprecht, Luca Arista, Angela Worby, Steve P Watson
Affiliations

The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure

Ian P Holmes et al. Bioorg Med Chem Lett. .

Abstract

The identification of a highly selective D(2) partial agonist, D(3) antagonist tool molecule which demonstrates high levels of brain exposure and selectivity against an extensive range of dopamine, serotonin, adrenergic, histamine, and muscarinic receptors is described.

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