Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Mar;36(2):243-5.
doi: 10.1093/schbul/sbq004. Epub 2010 Feb 12.

Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia

Colm M P O'Tuathaigh  1 , John L Waddington
Affiliations
Review

Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia

Colm M P O'Tuathaigh et al. Schizophr Bull. 2010 Mar.

Abstract

The present series of review articles seeks to elaborate how current findings in mutant mice may inform on the relationship between candidate genes and individual psychopathological and pathobiological aspects of schizophrenia. Each of the authors focuses on an overlapping selection of both well-characterized and emergent candidate genes, as identified through association and linkage studies and/or via their involvement in putative pathophysiological mechanisms, particularly those relating to dopaminergic and glutamatergic processes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Allen NC, Bagade S, McQueen MB, et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet. 2008;40:827–834. - PubMed
    1. Gill M, Donohoe G, Corvin A. What have the genomics ever done for the psychoses? Psychol Med. 2009;12:1–12. - PubMed
    1. Desbonnet L, Waddington JL, O'Tuathaigh CM. Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes? Behav Brain Res. 2009;204:258–273. - PubMed
    1. Kirby B, Waddington JL, O'Tuathaigh CMP. Advancing a functional genomics for schizophrenia: psychopathological and cognitive phenotypes in mutants with gene disruption [available online October 1, 2009] Brain Res Bull. doi:10.1016/j.brainresbull.2009.09.010. - PubMed
    1. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–645. - PubMed