Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Mar;6(3):159-161.
doi: 10.1038/nchembio.296.

The art of the chemical probe

Stephen V Frye  1
Affiliations

The art of the chemical probe

Stephen V Frye. Nat Chem Biol. 2010 Mar.
No abstract available

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
    Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, Palmer M, Shamji AF, Wawer MJ, McManus O, Wu M, Zou B, Yu H, Golden JE, Schoenen FJ, Simeonov A, Jadhav A, Jackson MR, Pinkerton AB, Chung TD, Griffin PR, Cravatt BF, Hodder PS, Roush WR, Roberts E, Chung DH, Jonsson CB, Noah JW, Severson WE, Ananthan S, Edwards B, Oprea TI, Conn PJ, Hopkins CR, Wood MR, Stauffer SR, Emmitte KA; NIH Molecular Libraries Project Team. Schreiber SL, et al. Cell. 2015 Jun 4;161(6):1252-65. doi: 10.1016/j.cell.2015.05.023. Cell. 2015. PMID: 26046436 Free PMC article. Review.
  • Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma.
    Hideshima T, Qi J, Paranal RM, Tang W, Greenberg E, West N, Colling ME, Estiu G, Mazitschek R, Perry JA, Ohguchi H, Cottini F, Mimura N, Görgün G, Tai YT, Richardson PG, Carrasco RD, Wiest O, Schreiber SL, Anderson KC, Bradner JE. Hideshima T, et al. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13162-13167. doi: 10.1073/pnas.1608067113. Epub 2016 Oct 31. Proc Natl Acad Sci U S A. 2016. PMID: 27799547 Free PMC article.
  • A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
    Scheer S, Ackloo S, Medina TS, Schapira M, Li F, Ward JA, Lewis AM, Northrop JP, Richardson PL, Kaniskan HÜ, Shen Y, Liu J, Smil D, McLeod D, Zepeda-Velazquez CA, Luo M, Jin J, Barsyte-Lovejoy D, Huber KVM, De Carvalho DD, Vedadi M, Zaph C, Brown PJ, Arrowsmith CH. Scheer S, et al. Nat Commun. 2019 Jan 3;10(1):19. doi: 10.1038/s41467-018-07905-4. Nat Commun. 2019. PMID: 30604761 Free PMC article.
  • Inhibitors and chemical probes for molecular chaperone networks.
    Gestwicki JE, Shao H. Gestwicki JE, et al. J Biol Chem. 2019 Feb 8;294(6):2151-2161. doi: 10.1074/jbc.TM118.002813. Epub 2018 Sep 13. J Biol Chem. 2019. PMID: 30213856 Free PMC article. Review.
  • The use of small molecules in somatic-cell reprogramming.
    Federation AJ, Bradner JE, Meissner A. Federation AJ, et al. Trends Cell Biol. 2014 Mar;24(3):179-87. doi: 10.1016/j.tcb.2013.09.011. Epub 2013 Oct 31. Trends Cell Biol. 2014. PMID: 24183602 Free PMC article. Review.
See all "Cited by" articles

References

    1. Nat Chem Biol. 2007 Dec;3(12):739-44 - PubMed
    1. J Med Chem. 2003 Oct 9;46(21):4477-86 - PubMed
    1. Nat Chem Biol. 2009 Jul;5(7):436-40 - PubMed
    1. Nat Biotechnol. 2008 Jan;26(1):127-32 - PubMed
    1. Science. 2008 Aug 8;321(5890):764-6 - PubMed