Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Mar;10(3):193-200.
doi: 10.1038/nri2727. Epub 2010 Feb 15.

Organization of immunological memory by bone marrow stroma

Koji Tokoyoda  1 , Anja E Hauser, Toshinori Nakayama, Andreas Radbruch
Affiliations
Review

Organization of immunological memory by bone marrow stroma

Koji Tokoyoda et al. Nat Rev Immunol. 2010 Mar.

Abstract

Immunological memory is a hallmark of the adaptive immune system. Plasma cells and memory B and T cells collectively provide protective immunity and effective secondary immune responses to invading pathogens. Here, we discuss how mesenchymal stromal cells regulate immunological memory by organizing defined numbers of dedicated survival niches for plasma cells and memory T cells in the bone marrow and also, to a lesser extent, in secondary lymphoid organs. An understanding of the biology of mesenchymal stromal cells and their interaction with cells of the immune system is key to fully understanding immunological memory.

PubMed Disclaimer

Comment in

References

    1. Br J Haematol. 1981 Jun;48(2):287-91 - PubMed
    1. Science. 2000 Oct 6;290(5489):127-31 - PubMed
    1. Blood. 2005 Feb 15;105(4):1815-22 - PubMed
    1. Blood. 2009 Jan 1;113(1):214-23 - PubMed
    1. J Immunol. 2007 Mar 1;178(5):2973-8 - PubMed

Publication types

LinkOut - more resources