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. 2010 Mar 8;12(2):292-4.
doi: 10.1021/cc900195t.

Regio- and stereoselective synthesis of novel dispiropyrrolidine bisoxindole derivatives via multicomponent reactions

Hai Liu  1 , Guolan Dou, Daqing Shi
Affiliations

Regio- and stereoselective synthesis of novel dispiropyrrolidine bisoxindole derivatives via multicomponent reactions

Hai Liu et al. J Comb Chem. .

Abstract

A convenient and efficient method for the synthesis of novel dispiropyrrolidine bisoxindole derivatives by 1,3-dipolar cycloaddition reaction of azomethine ylides has been developed. The synthesis was achieved by using a one-pot multicomponent procedure. The features of this procedure were characterized by the following: mild reaction conditions, high yields, high regio- and stereoselectivity, one-pot procedure, and operational simplicity.

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