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. 1991 May 1;51(9):2490-3.

Somatic allelic deletion of nm23 in human cancer

A Leone  1 , O W McBride, A Weston, M G Wang, P Anglard, C S Cropp, J R Goepel, R Lidereau, R Callahan, W M Linehan, et al.
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  • PMID: 2015608

Somatic allelic deletion of nm23 in human cancer

A Leone et al. Cancer Res. .

Abstract

Tumor progression to the metastatic phenotype is accompanied in certain cell types by reduced expression of the nm23 gene. We have localized human nm23-H1 to chromosome 17 by somatic cell hybrid analysis. Regional localization in the CEPH database and in situ hybridization is reported. Somatic allelic deletion of nm23-H1 was observed in human breast, renal, colorectal, and lung carcinoma DNA samples, as compared to DNA from matched normal tissues. A homozygous deletion of nm23-H1 was observed in a lymph node metastasis of a colorectal carcinoma, indicating that nm23-H1 can be recessively inactivated. The data identify nm23-H1 as a novel, independent locus for allelic deletion in human cancer, a characteristic shared with previously described suppressor genes.

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