Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Mar;7(1):46-53.
doi: 10.2174/157016310791162785.

Targeting tumor proteasome with traditional Chinese medicine

Huanjie Yang  1 , Jinbao Liu, Q Ping Dou
Affiliations
Review

Targeting tumor proteasome with traditional Chinese medicine

Huanjie Yang et al. Curr Drug Discov Technol. 2010 Mar.

Abstract

The proteasome is a multicatalytic protease complex whose activity is required for the growth of normal or tumor cells. It has been shown that human cancer cells are more sensitive to proteasome inhibition than normal cells, indicating that the proteasome could be a target of chemotherapy. Studies suggest that traditional Chinese medicine (TCM) is an effective approach for cancer treatment. Here we reviewed several TCMs for their potential in treatment of cancer. This short review focuses mainly on the TCMs that potentially target the tumor cellular proteasome and NF-kappaB pathway whose activation is dependent on the proteasome activity.

PubMed Disclaimer

Figures

Fig. (1)
Fig. (1)
Chemical structures of compounds isolated from TCMs.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell. 1994;79(1):13–21. - PubMed
    1. Ciechanover A. The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J. 1998;17(24):7151–60. - PMC - PubMed
    1. Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature. 2003;426(6968):895–99. - PubMed
    1. Dou QP, Smith DM, Daniel KG, Kazi A. Interruption of tumor cell cycle progression through proteasome inhibition: implications for cancer therapy. Prog Cell Cycle Res. 2003;5:441–6. - PubMed
    1. Pickart CM, Cohen RE. Proteasomes and their kin: proteases in the machine age. Nat Rev Mol Cell Biol. 2004;5(3):177–87. - PubMed

Publication types

MeSH terms