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. 2009 Dec 7;14 Suppl 4(Suppl 4):6-8.
doi: 10.1186/2047-783x-14-s4-6.

Exhaled nitric oxide - circadian variations in healthy subjects

M Antosova  1 , A Bencova, A Psenkova, D Herle, E Rozborilova
Affiliations

Exhaled nitric oxide - circadian variations in healthy subjects

M Antosova et al. Eur J Med Res. .

Abstract

Objective: Exhaled nitric oxide (eNO) has been suggested as a marker of airway inflammatory diseases. The level of eNO is influenced by many various factor including age, sex, menstrual cycle, exercise, food, drugs, etc. The aim of our study was to investigate a potential influence of circadian variation on eNO level in healthy subjects.

Methods: Measurements were performed in 44 women and 10 men, non-smokers, without respiratory tract infection in last 2 weeks. The eNO was detected at 4-hour intervals from 6 a.m. to 10 p.m. using an NIOX analyzer. We followed the ATS/ERS guidelines for eNO measurement and analysis.

Results: Peak of eNO levels were observed at 10 a.m. (11.1 +/- 7.2 ppb), the lowest value was detected at 10 p.m. (10.0 +/- 5.8 ppb). The difference was statistically significant (paired t-test, P<0.001).

Conclusions: The daily variations in eNO, with the peak in the morning hours, could be of importance in clinical practice regarding the choice of optimal time for monitoring eNO in patients with respiratory disease.

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Figures

Figure 1
Figure 1
Exhaled NO mean values.
Figure 2
Figure 2
Exhaled NO mean values in women and men.
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References

    1. Gustafsson LE, Leone AM, Person MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun. 1991;181:852–7. doi: 10.1016/0006-291X(91)91268-H. - DOI - PubMed
    1. Hyde RW, Geigel EJ, Olszowska AJ, Krasmeu JA, Forster RE, Utell MJ, Frampton MW. Determination of production of nitric oxide by lower airways of humans: theory. J Appl Physiol. 1997;82:1290–6. - PubMed
    1. Nijkamp FP, Folkerts G. Nitric oxide: initiator and modulator. Clin Exp Allergy. 1997;27:347–50. doi: 10.1111/j.1365-2222.1997.tb00716.x. - DOI - PubMed
    1. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994;343:133–35. doi: 10.1016/S0140-6736(94)90931-8. - DOI - PubMed
    1. Dweik RA. The promise and reality of nitric oxide in the diagnosis and treatment of lung disease. Cleveland Clin J Med. 2001;68(6):486–90. doi: 10.3949/ccjm.68.6.486. - DOI - PubMed

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