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. 2009 Dec 7;14 Suppl 4(Suppl 4):121-5.
doi: 10.1186/2047-783x-14-s4-121.

Differential ion mobility spectroscopy: non-invasive real-time diagnostics and therapy control in metabolic diseases

A Kikowatz  1 , G Becher, S Dietze, W Steinhäusser, E Beck
Affiliations

Differential ion mobility spectroscopy: non-invasive real-time diagnostics and therapy control in metabolic diseases

A Kikowatz et al. Eur J Med Res. .

Abstract

Background: Over the last few years, differential ion mobility spectroscopy (DMS) has become an important tool in medical research. There are attempts to find markers for specific diseases in exhaled air, using this technology as a non-invasive early diagnosis.

Objective: In the present research, exhaled air from 78 patients with known diagnosis and 39 control persons were tested with a DMS system from Sionex.

Results: Bronchial asthma showed a pattern of 6 characteristic points in a discriminant analysis. Patients with diagnosed hypertension showed a characteristic pattern with 4 points, hypothyroidism 2 points; increased LDL cholesterol 3 points, and type II diabetics treated with insulin 4 spots. No significant differences with respect to the control group were found in chronic obstructive pulmonary disease patients. The DMS pattern in the tested asthmatics showed a partial change depending on different medications used.

Conclusion: Differential ion mobility spectroscopy offers promise as a helpful diagnostic tool.

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Figures

Figure 1
Figure 1
Differential mass spectroscopy.
Figure 2
Figure 2
Occurrence of different diseases in the tested population.
Figure 3
Figure 3
Cluster analysis. The upper pictures show the positive and negative spectrums from one patient, without allocating the different points. The lower pictures show the same spectrum after allocating several points to groups using cluster analysis.
See this image and copyright information in PMC

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