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. 2009 Dec 7;14 Suppl 4(Suppl 4):196-200.
doi: 10.1186/2047-783x-14-s4-196.

Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children

B Pyrzak  1 , A Wisniewska, A Majcher, K Popko, M Wasik, U Demkow
Affiliations

Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children

B Pyrzak et al. Eur J Med Res. .

Abstract

Objective: The aim of the study was to investigate whether the G-174C polymorphism of the IL-6 gene is related to obesity and the incidence of the metabolic syndrome (MetS) according to IDF definition in children.

Materials and methods: The examined group included 124 obese children with BMI > or = 2 SDS, and the control group consisted of 56 non-obese children with BMI <1.0 SDS. Polymorphism identification was performed in total genomic DNA using PCR-RFLP method.

Results: In the obese children, carriers of C allele in homozygotic and heterozygotic genotypes were more frequent than in the control group. The carriers of C alleles presented with lower thickness of subcutaneous tissue and higher concentrations of HDL-C than the wild type. The incidence of MetS was 33% of the group of obese children. Analysis of the presence of MetS factors showed that there is more frequent MetS in the group with the wild homozygous genotype type.

Conclusion: Polymorphism 174G>C in the IL-6 gene does not seem to be associated with obesity and with the incidence of MetS in children.

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Figures

Figure 1
Figure 1
Distribution of IL-6 genotypes in obese children vs. control group.
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