Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2010 Jan;47(1):68-70.
doi: 10.3340/jkns.2010.47.1.68. Epub 2010 Jan 31.

Intracranial dissemination from spinal cord anaplastic astrocytoma

Seong Man Jeong  1 , Yong Gu Chung, Jang Bo Lee, Il Young Shin
Affiliations
Case Reports

Intracranial dissemination from spinal cord anaplastic astrocytoma

Seong Man Jeong et al. J Korean Neurosurg Soc. 2010 Jan.

Abstract

We report a case of intracranial dissemination developing approximately 4 months after partial removal of a spinal cord anplastic astrocytoma in a 22-year-old male. He presented with paraplegia on initial admission at a local hospital. Spinal magnetic resonance (MR) images disclosed multiple intramedullary lesions at the T3-11. The tumor was partially removed. The final histologic diagnosis was anaplastic astrocytoma. Four months after the operation, he was admitted with the symptoms of headache and deterioration of consciousness. MR images showed enhanced lesions in the anterior horn of the left lateral ventricle, and septum pellucidum. He underwent computed tomography-guided stereotactic biopsy and histological appearance was consistent with anaplastic astrocytoma. The clinical course indicates that the tumor originated in the spinal cord and extended into the subarachnoid space, first the spinal canal and later intracranial.

Keywords: Anaplastic astrocytoma; Intracranial dissemination; Spinal cord.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
A : Spinal T2-weighted magnetic resonance (MR) image (left), T1-weighted image (middle), and T1-weighted enhanced image (right) showing an intramedullary spinal tumor at T8-11 levels. B : Brain T2-weighted MR image (left) and T1-weighted enhanced images (middle and right) showing no evidence intracranial tumor
Fig. 2
Fig. 2
A : Spinal T2-weighted magnetic resonance (MR) image (left), T1-weighted image (middle), and T1-weighted enhanced image (right) showing an intramedullary spinal tumor at T3-11 levels and distant seeding to L2 level. B : Brain T2-weighted MR image (left) and T1-weighted enhanced images (middle and right) showing enhanced lesions in the anterior horn of the left lateral ventricle, septum pellucidum.
Fig. 3
Fig. 3
A : Photomicrograghs of a specimen from brain tumor. The photogragh reveals anaplastic astrocytoma with moderate celluarity and pleomorphic nuclei (H & E, ×400). B : Photomicrogragh of a specimen from spinal tumor. The photogragh reveals same findings of brain specimen (H & E, ×400). C : Photomicrogragh of a specimen from spinal tumor. The photogragh reveals Ki-67/MIB-1 labeling index 10-20%.
See this image and copyright information in PMC

References

    1. Asano N, Kitamura K, Seo Y, Mukai K, Soga T, Hondo H, et al. Spinal cord glioblastoma multiforme with intracranial dissemination-case report. Neurol Med Chir. Neurol Med Chir (Tokyo) 1990;30:489–494. - PubMed
    1. Bell WO, Packer RJ, Seigel KR, Rorke LB, Sutton LN, Bruce DA, et al. Leptomeningeal spread of intramedullary spinal cord tumors. Report of three cases. J Neurosurg. 1988;69:295–300. - PubMed
    1. Cohen AR, Wisoff JH, Allen JC, Epstein F. Malignant astrocytomas of the spinal cord. J Neurosurg. 1989;70:50–54. - PubMed
    1. Faria MH, Gonçalves BP, do Patrocínio RM, de Moraes-Filho MO, Rabenhorst SH. Expression of Ki-67, topoisomerase IIalpha and c-MYC in astrocytic tumors : correlation with the histopathological grade and proliferative status. Neuropathology. 2006;26:519–527. - PubMed
    1. Johannessen AL, Torp SH. The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas. Pathol Oncol Res. 2006;12:143–147. - PubMed

Publication types

LinkOut - more resources