Review
doi: 10.18632/aging.100040.
Growth and aging: a common molecular mechanism
Affiliations
- PMID: 20157523
- PMCID: PMC2806018
- DOI: 10.18632/aging.100040
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Review
Growth and aging: a common molecular mechanism
Aging (Albany NY).
.
Abstract
It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.
Keywords: TOR; aging; growth; mitochondria; rapamycin.
Conflict of interest statement
The authors declare no conflict of interests.
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