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Review
. 2009 Apr 20;1(4):357-62.
doi: 10.18632/aging.100040.

Growth and aging: a common molecular mechanism

Mikhail V Blagosklonny  1 , Michael N Hall
Affiliations
Review

Growth and aging: a common molecular mechanism

Mikhail V Blagosklonny et al. Aging (Albany NY). .

Abstract

It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.

Keywords: TOR; aging; growth; mitochondria; rapamycin.

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Conflict of interest statement

The authors declare no conflict of interests.

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