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. 2009 Jul 24;1(8):714-22.
doi: 10.18632/aging.100071.

Human insulin/IGF-1 and familial longevity at middle age

Maarten P Rozing  1 , Rudi G J Westendorp, Marijke Frölich, Anton J M de Craen, Marian Beekman, Bastiaan T Heijmans, Simon P Mooijaart, Gerard-Jan Blauw, P Eline Slagboom, Diana van Heemst; Leiden Longevity Study (LLS) Group
Collaborators, Affiliations

Human insulin/IGF-1 and familial longevity at middle age

Maarten P Rozing et al. Aging (Albany NY). .

Abstract

Recently, we have shown that compared to controls, long-lived familial nonagenarians (mean age: 93.4 years) from the Leiden Longevity Study displayed a lower mortality rate, and their middle-aged offspring displayed a lower prevalence of cardio-metabolic diseases, including diabetes mellitus. The evolutionarily conserved insulin/IGF-1 signaling (IIS) pathway has been implicated in longevity in model organisms, but its relevance for human longevity has generated much controversy. Here, we show that compared to their partners, the offspring of familial nonagenarians displayed similar non-fasted serum levels of IGF-1, IGFBP3 and insulin but lower non-fasted serum levels of glucose, indicating that familial longevity is associated with differences in insulin sensitivity.

Keywords: IGF-1; IGFBP3; familial longevity; glucose handling; height.

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Conflict of interest statement

The authors of this manuscript have no conflict of interests to declare.

Figures

Figure 1.
Figure 1.. Cumulative distribution curves of serum IGF-1 levels, serum IGFBP3 levels and height.
Cumulative distribution curves of IGF-1 levels for offspring and partners among females (A) and males (B); Cumulative distribution curves of IGFBP3 levels for offspring and partners among females (C) and males (D); Cumulative distribution curves of height for offspring and partners among females (E) and males (F). Black lines represent offspring, gray lines represent partners.
Figure 2.
Figure 2.
Association between age categories and serum IGF-1 levels for offspring and partners among females (A) and males (B) and association between age categories and serum IGFBP3 levels for offspring and partners among females (C) and males (D). Dark bars represent offspring, light bars represent partners. Number of participants per age category for females (offspring/ partners): category <55: 156/110; category 55-60: 194/83; category 60-65: 146/66; category >65: 114/27. Number of participants per age category for males (offspring/ partners): category <55: 133/42; category 55-60: 140/49; category 60-65: 140/57; category >65: 102/66.
See this image and copyright information in PMC

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